Cisplat 50 Mg Cisplatin Injection

Cisplat 50 Mg Cisplatin Injection

Product Details:

  • Drug Type Injection
  • Physical Form Liquid
  • Dosage 50 Mg
  • Suitable For Adults, Women
  • Supply Ability : 100000 Piece Per Week
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Price And Quantity

  • 100000 Piece
  • 477 INR

Product Specifications

  • Adults, Women
  • 50 Mg
  • Liquid
  • Injection

Trade Information

  • Cash in Advance (CID), Cash Advance (CA)
  • 100000 Piece Per Week
  • 1 Week
  • Africa, Middle East, Western Europe, Eastern Europe, South America, North America, Central America, Australia, Asia

Product Description

TYPICAL USAGE

Bladder carcinoma, metastatic germ cell cancers (seminoma and teratoma), metastatic ovarian carcinoma, metastatic testicular cancer, non-small cell lung carcinoma, small cell lung cancer.

SIDE EFFECTS

Neuropathy, hypersensitivity reactions, ototoxicity, reduction in creatinine clearance, elevation in serum creatinine, vascular toxicity.

DRUG INTERACTION

Cisplatin is known to interact with other drugs like amphotericin B, bleomycin, capreomycin, diazoxide, etoposide, fluorouracil, fosphenytoin, frusemide or furosemide, gallium nitrate, gemcitabine, gentamicin, hydralazine (HCl), ifosfamide, mannitol, netilmicin (Sulphate), paclitaxel, podophyllum, propranolol (HCl), rituximab, tacrolimus, tobramycin. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.

MECHANISM OF ACTION

Cisplatin work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA. 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription. 3) the induction of mispairing of the nucleotides leading to mutations.


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