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VANTOX-CP 1 GM
Typical Usages of VANTOX-CP 1 GM:
Bacteremia, brain abscesses, endocarditis, endocarditis prophylaxis, chronic myeloid leukaemia, acute leukemia, colitis, constipation and bowel evacuation, meningitis, peritonitis, endocarditis treatment, relentless neutropenia in advanced HIV contagion.
Pregnancy:C Lactation:L5 Lab:NA Food:NA
Nephrotoxicity, renal damage, uremia, hematuria, proteinuria, fever, redness, hypotension, flushing, urticarial skin rash, eosinophilia, red man syndrome.
Vancomycin is known to interact with other drugs like amphotericin B, cyclosporin A, gentamicin, metformin (HCl), netilmicin (Sulphate), oxaliplatin, streptomycin, tobramycin. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Mechanism Of Action
Vancomycin prevents incorporation of N-acetylmuramic acid (NAM)- and N-acetylglucosamine (NAG)-peptide subunits from being incorporated into the peptidoglycan matrix; which forms the major structural component of Gram-positive cell walls. The large hydrophilic molecule is able to form hydrogen bond interactions with the terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides. This binding of vancomycin to the D-Ala-D-Ala prevents the incorporation of the NAM/NAG-peptide subunits into the peptidoglycan matrix and alters bacterial-cell-membrane permeability and RNA synthesis.