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Bacteremia, brain abscesses, acute leukemia, constipation and bowel evacuation, meningitis, endocarditis, chronic myeloid leukaemia, colitis, peritoneal inflammation, endocarditis treatment, endocarditis prophylaxis, relentless neutropenia in advanced HIV infection.
Pregnancy:L5 Lab: C Lactation: NA Food:NA
Mechanism Of Action
Vancomycin prevents integration of N-acetylmuramic acid (NAM)- and N-acetylglucosamine (NAG)-peptide subunits from being unified into the peptidoglycan intercellular substance; which makes the major functional constituent of Gram-positive cell walls. The sizable hydrophilic molecule is capable to make hydrogen bond interactions with the endmost D-alanyl-D-alanine portions of the NAM/NAG-peptides. The binding of vancomycin to the D-Ala-D-Ala precludes the consolidation of the NAM/NAG-peptide subunits into the peptidoglycan substance and changes bacterial-cell-membrane porosity as well as RNA synthesis.