Emeset - Emeset or GlaxoSmithKline's Zofran is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic to treat nausea and vomiting following chemotherapy. Its effects are thought to be on both peripheral and central nerves. Emeset reduces the activity of the vagus nerve, which activates the vomiting center in the medulla oblongata, and also blocks serotonin receptors in the chemoreceptor trigger zone. It has little effect on vomiting caused by motion sickness, and does not have any effect on dopamine receptors or muscarinic receptors.
Emeset is used to prevent nausea and vomiting due to cancer chemotherapy or radiation therapy. It is also used to prevent nausea and vomiting after surgery.
Indications: nausea and vomiting induced by radiotherapy or chemotherapy, postoperative nausea and vomiting
Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy, including high-dose cisplatin. Prevention of postoperative nausea and/or vomiting. In patients where nausea and/or vomiting must be avoided post operatively, Danset ampoule is recommended even where the incidence of postoperative nausea and/or vomiting is low. For patients who do not receive prophylactic Danset ampoule and experience nausea and/or vomiting post operatively, Danset ampoule may be given to prevent further episodes.