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DILZEM-30

DILZEM-30
DILZEM-30
Product Code : 00164
Product Description
Dilzem - Dilzem Hydrochloride for Injection is a calcium ion influx inhibitor (slow channel blocker or calcium channel antagonist). This drug product is not for direct bolus injection. Text referring to direct bolus injection is provided for information purposes only. Dilzem Hydrochloride for Injection is indicated for the following: Temporary control of rapid ventricular rate in atrial fibrillation or atrial flutter. It should not be used in patients with atrial fibrillation or atrial flutter associated with an accessory bypass tract such as in Wolff-Parkinson-White (WPW) syndrome or short PR syndrome. Rapid conversion of paroxysmal supraventricular tachycardias (PSVT) to sinus rhythm. This includes AV nodal reentrant tachycardias and reciprocating tachycardias associated with an extranodal accessory pathway such as the WPW syndrome or short PR syndrome. Unless otherwise contraindicated, appropriate vagal maneuvers should be attempted prior to administration of Dilzem hydrochloride injection. The use of Dilzem hydrochloride should be undertaken with caution when the patient is compromised hemodynamically or is taking other drugs that decrease any or all of the following: peripheral resistance, myocardial filling, myocardial contractility, or electrical impulse propagation in the myocardium. In domestic controlled trials in patients with atrial fibrillation or atrial flutter, bolus administration of Dilzem hydrochloride injection was effective in reducing heart rate by at least 20% in 95% of patients. Dilzem hydrochloride injection rarely converts atrial fibrillation or atrial flutter to normal sinus rhythm. Following administration of one or two intravenous bolus doses of Dilzem hydrochloride injection, response usually occurs within 3 minutes and maximal heart rate reduction generally occurs in 2 to 7 minutes. Heart rate reduction may last from 1 to 3 hours. If hypotension occurs, it is generally short-lived, but may last from 1 to 3 hours. A 24-hour continuous infusion of Dilzem injection in the treatment of atrial fibrillation or atrial flutter maintained at least a 20% heart rate reduction during the infusion in 83% of patients. Upon discontinuation of infusion, heart rate reduction may last from 0.5 hours to more than 10 hours (median duration 7 hours). Hypotension, if it occurs, may be similarly persistent. In the controlled clinical trials, 3.2% of patients required some form of intervention (typically, use of intravenous fluids or the Trendelenburg position) for blood pressure support following Dilzem hydrochloride injection. In domestic controlled trials, bolus administration of Dilzem hydrochloride injection was effective in converting PSVT to normal sinus rhythm in 88% of patients within 3 minutes of the first or second bolus dose. Symptoms associated with the arrhythmia were improved in conjunction with decreased heart rate or conversion to normal sinus rhythm following administration of Dilzem hydrochloride injection. Dilzem is a Calcium Channel Blocker usually used to treat blood pressure. Some of the most prescribed drugs in this class include: Norvasc. Active ingredients: Diltiazem

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