Bladder carcinoma, metastatic germ cell cancers (seminoma and teratoma), metastatic ovarian carcinoma, metastatic testicular cancer, non-small cell lung carcinoma, small cell lung cancer.
Neuropathy, hypersensitivity reactions, ototoxicity, reduction in creatinine clearance, elevation in serum creatinine, vascular toxicity.
Cisplatin is known to interact with other drugs like amphotericin B, bleomycin, capreomycin, diazoxide, etoposide, fluorouracil, fosphenytoin, frusemide or furosemide, gallium nitrate, gemcitabine, gentamicin, hydralazine (HCl), ifosfamide, mannitol, netilmicin (Sulphate), paclitaxel, podophyllum, propranolol (HCl), rituximab, tacrolimus, tobramycin. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
MECHANISM OF ACTION
Cisplatin work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA. 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription. 3) the induction of mispairing of the nucleotides leading to mutations.