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Why Is it Used ?
DISULFIRAM :Adjunct to treatment of chronic alcoholism.
What Precautions should be taken ?
DISULFIRAM :Hypersensitivity, CVS diseases; peripheral neuropathy, psychosis. Not to be used in patients with alcohol intoxication.
Interaction with other medicines...
Potentially Fatal: Disulfiram-alcohol interaction: Intense flushing of neck and face accompanied by heat and sweating, tachycardia, palpitation, dyspnoea, dizziness, headache, HTN initially and then hypotension; GI disturbances, exhaustion, convulsions and cardiopulmonary arrest.
DISULFIRAM :Inhibits hepatic enzymes thus interferes with metabolism of other drugs; enhances anticoagulant effects of phenytoin and coumarin. Adverse CNS effects may be precipitated with concurrent metronidazole, INH or MAOI therapy. Tricyclic antidepressants exacerbate symptoms of disulfiram-alcohol reaction.
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