Why Is it Used ?
ATORVASTATIN :Adult: PO Mixed dyslipidaemia; Nonfamilial hypercholesterolaemia; Heterozygous familial hypercholesterolaemia Inital: 10 or 20 mg once daily, may increase slowly if needed. Max: 80 mg/day.
What are the Side Effects ?
ATORVASTATIN :Headache, flatulence, diarrhoea, nausea, vomiting, anorexia, xerostomia, angioedema, myalgia, rash/pruritus, alopecia, allergy, infection, chest pain. Potentially Fatal: Thrombocytopenia. Rhabdomyolysis with acute renal failure.
What Precautions should be taken ?
ATORVASTATIN :Patients who consume substantial quantities of alcohol. History of liver disease. Patients with risk factors for myopathy or rhabdomyolysis. Hypothyroidism should be properly managed prior to starting statin therapy. Children <10 yr. Premenarcheal females.
Do not take this if you have any of the below ...
ATORVASTATIN :Hypersensitivity, active liver disease or unexplained persistent elevations of serum transaminase, porphyria, pregnancy, lactation.
Interaction with other medicines...
ATORVASTATIN :Increased AUC for norethindrone and ethinyl estradiol. Concomitant multiple doses of atorvastatin and digoxin increased steady-state digoxin levels. Increased risk of rhabdomyolysis when used concurently with fibrates. Co-admin with antacid suspensions and colestipol decreased atorvastatin levels.