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ALPHADOL 0.25MG

ALPHADOL 0.25MG
ALPHADOL 0.25MG
Product Code : 0072
Product Description
DESCRIPTION 
Alphadol 
Red, transparent, round, soft gelatin capsules, containing pale yellow coloured clear oily liquid. 
Alphadol-1 
Green, transparent, round, soft gelatin capsules, containing pale yellow colored clear oily liquid. 
 
COMPOSITION 
Alphadol 
Each soft gelatin capsule contains : 
Alfacalcidol BP. 0.25 mcg (1α-hydroxyvitamin D3) 
Approved colours used in capsule shells. 
Alphadol-1 
Each soft gelatin capsule contains : 
Alfacalcidol BP. 1mcg (1α-hydroxyvitamin D3) 
Colours: Brilliant Blue & Tartrazine 
 
PHARMACOLOGY Alfacalcidol is fat soluble and upto 100% absorption normally takes place. After absorption, 
alfacalcidol is rapidly hydroxylated at 2 position, predominantly in liver although the enzyme is 
widely distributed in body tissues.1 Alfacalcidol (1α-hydroxyvitamin D3) undergoes rapid hepatic 
conversion to 1,25-dihydroxyvitamin D3, which acts as a regulator of calcium and phosphate 
metabolism. Due to this rapid conversion, the therapeutic benefits of alfacalcidol are virtually the 
same as those of 1,25-dihydroxyvitamin D3.
2 The main effects are to increase circulating 1,25-
dihydroxyvitamin D3 levels, and thereby to increase intestinal absorption of calcium and 
phosphate, promote bone mineralisation, regulate plasma parathyroid hormone levels as well as 
to decrease bone resorption, with relief of bone and muscle pain. 

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